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Visium

Human aortic valve leaflet

GSM9759910

bronze Interactive viewer H&E aortic valve stenosis Provisional
Human aortic valve leaflet preview
print(sdata)
SpatialData object
├── Images
│     ├── 'GSM9759910_Patient_20V_hires_image': DataArray[cyx] (3, 2000, 1911)
│     └── 'GSM9759910_Patient_20V_lowres_image': DataArray[cyx] (3, 600, 573)
├── Shapes
│     └── 'GSM9759910_Patient_20V': GeoDataFrame shape: (1713, 2) (2D shapes)
└── Tables
      └── 'table': AnnData (1713, 36601)
with coordinate systems:
    ▸ 'GSM9759910_Patient_20V', with elements:
        GSM9759910_Patient_20V_hires_image (Images), GSM9759910_Patient_20V_lowres_image (Images), GSM9759910_Patient_20V (Shapes)
    ▸ 'GSM9759910_Patient_20V_downscaled_hires', with elements:
        GSM9759910_Patient_20V_hires_image (Images), GSM9759910_Patient_20V (Shapes)
    ▸ 'GSM9759910_Patient_20V_downscaled_lowres', with elements:
        GSM9759910_Patient_20V_lowres_image (Images), GSM9759910_Patient_20V (Shapes)
Python · sddb client
from sddb import Catalog

ds = Catalog().dataset("TVXQMNo2xos3PGbo0000")
ds.elements()          # inspect without downloading
sdata = ds.to_sdata()  # cached locally, reused
print(sdata)
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
artifact = db.Artifact.get("TVXQMNo2xos3PGbo")   # stem uid: Lamin resolves it to the latest version

sdata = artifact.load()   # cache, then load into memory
group = artifact.open()   # stream without downloading
path  = artifact.cache()  # sync into the local cache, returns the path
Shell
# sddb client: download the .zarr into data/
sddb-cli download TVXQMNo2xos3PGbo0000 --dest data/

# or lamin: cache the dataset and print its local path
lamin load https://lamin.ai/scverse/spatialdata-db/artifact/TVXQMNo2xos3PGbo

# or connect once, then load by uid
lamin connect scverse/spatialdata-db
lamin load artifact --uid TVXQMNo2xos3PGbo

License: NCBI GEO policy

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Metadata

Technology
Visium
Organism
human
Tissue
aortic valve leaflet
Condition
aortic valve stenosis
Modality
RNA
Observations (spots)
1,713
Tier
bronze
Chemistry
Visium v1
Magnification
other
Resolution
1,911 × 2,000 px
mpp
3.479 µm/px
Size
7.5 MB
Sample ID
GSM9759910
License
NCBI GEO policy
Published
Jun 3, 2026

Cite this dataset

doi.org/10.1161/atvbaha.126.324694 ↗
BibTeX
@article{Baddour_2026,
  title = {Spatial and Single-Cell Mapping Reveals Valvular Interstitial Cell and Macrophage Sex Differences in Calcific Aortic Valve Disease},
  volume = {46},
  ISSN = {1524-4636},
  url = {http://dx.doi.org/10.1161/atvbaha.126.324694},
  DOI = {10.1161/atvbaha.126.324694},
  number = {7},
  journal = {Arteriosclerosis, Thrombosis, and Vascular Biology},
  publisher = {Ovid Technologies (Wolters Kluwer Health)},
  author = {Baddour, Talia and Ninh, Van K. and Gorashi, Rayyan M. and Peña, Rene and King, Kevin R. and Aguado, Brian A.},
  year = {2026},
  month = July
}

Source: NCBI GEO ↗ · License: NCBI GEO policy ↗ · Reprocessed to SpatialData by SpatialData-DB