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Visium HD

Human lymph node

GSM8658293

bronze Interactive viewer H&E prostate cancer Provisional
Human lymph node preview
print(sdata)
SpatialData object
├── Images
│     ├── 'GSM8658293_SI_38469_hires_image': DataArray[cyx] (3, 5795, 6000)
│     └── 'GSM8658293_SI_38469_lowres_image': DataArray[cyx] (3, 580, 600)
├── Shapes
│     ├── 'GSM8658293_SI_38469_square_008um': GeoDataFrame shape: (162379, 1) (2D shapes)
│     └── 'GSM8658293_SI_38469_square_008um_for_vitessce': GeoDataFrame shape: (162379, 2) (2D shapes)
└── Tables
      └── 'square_008um': AnnData (162379, 18085)
with coordinate systems:
    ▸ 'GSM8658293_SI_38469', with elements:
        GSM8658293_SI_38469_hires_image (Images), GSM8658293_SI_38469_lowres_image (Images), GSM8658293_SI_38469_square_008um (Shapes), GSM8658293_SI_38469_square_008um_for_vitessce (Shapes)
    ▸ 'GSM8658293_SI_38469_downscaled_hires', with elements:
        GSM8658293_SI_38469_hires_image (Images), GSM8658293_SI_38469_square_008um (Shapes), GSM8658293_SI_38469_square_008um_for_vitessce (Shapes)
    ▸ 'GSM8658293_SI_38469_downscaled_lowres', with elements:
        GSM8658293_SI_38469_lowres_image (Images), GSM8658293_SI_38469_square_008um (Shapes), GSM8658293_SI_38469_square_008um_for_vitessce (Shapes)
Python · sddb client
from sddb import Catalog

ds = Catalog().dataset("HiYzMrU5llDCaNSz0002")
ds.elements()          # inspect without downloading
sdata = ds.to_sdata()  # cached locally, reused
print(sdata)
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
artifact = db.Artifact.get("HiYzMrU5llDCaNSz")   # stem uid: Lamin resolves it to the latest version

sdata = artifact.load()   # cache, then load into memory
group = artifact.open()   # stream without downloading
path  = artifact.cache()  # sync into the local cache, returns the path
Shell
# sddb client: download the .zarr into data/
sddb-cli download HiYzMrU5llDCaNSz0002 --dest data/

# or lamin: cache the dataset and print its local path
lamin load https://lamin.ai/scverse/spatialdata-db/artifact/HiYzMrU5llDCaNSz

# or connect once, then load by uid
lamin connect scverse/spatialdata-db
lamin load artifact --uid HiYzMrU5llDCaNSz

License: NCBI GEO policy

View on Lamin ↗ Open in Vitessce ↗ Flag a data issue

Metadata

Technology
Visium HD
Organism
human
Tissue
lymph node
Condition
prostate cancer
Modality
RNA
Observations (bins)
162,379
Tier
bronze
Resolution
6,000 × 5,795 px
mpp
1.603 µm/px
Size
260 MB
Sample ID
GSM8658293
License
NCBI GEO policy
Published
Jun 23, 2025

Cite this dataset

doi.org/10.1172/jci193745 ↗
BibTeX
@article{Bao_2025,
  title = {CDK12/13 inactivation triggers STING-mediated antitumor immunity in preclinical models},
  volume = {135},
  ISSN = {1558-8238},
  url = {http://dx.doi.org/10.1172/jci193745},
  DOI = {10.1172/jci193745},
  number = {18},
  journal = {Journal of Clinical Investigation},
  publisher = {American Society for Clinical Investigation},
  author = {Bao, Yi and Chang, Yu and Tien, Jean Ching-Yi and Cruz, Gabriel and Yang, Fan and Mannan, Rahul and Mahapatra, Somnath and Paturu, Radha and Cao, Xuhong and Su, Fengyun and Wang, Rui and Zhang, Yuping and Gondal, Mahnoor and Choi, Jae Eun and Gurkan, Jonathan K. and Miner, Stephanie J. and Robinson, Dan R. and Wu, Yi-Mi and Zhou, Licheng and Wang, Zhen and Kryczek, Ilona and Wang, Xiaoju and Cieslik, Marcin and Qiao, Yuanyuan and Tsodikov, Alexander and Zou, Weiping and Ding, Ke and Chinnaiyan, Arul M.},
  year = {2025},
  month = July
}

Source: NCBI GEO ↗ · License: NCBI GEO policy ↗ · Reprocessed to SpatialData by SpatialData-DB