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spatial transcriptomics

Human skin of body

NCBI760

silver Interactive viewer H&E skin squamous cell carcinoma ✓ Verified publication
Human skin of body preview
print(sdata)
SpatialData object
├── Images
│     └── 'NCBI760_full_image': DataTree[cyx] (3, 15872, 15872), (3, 7936, 7936), (3, 3968, 3968), (3, 1984, 1984)
├── Shapes
│     └── 'NCBI760_spots': GeoDataFrame shape: (621, 2) (2D shapes)
└── Tables
      └── 'table': AnnData (621, 15684)
with coordinate systems:
    ▸ 'global', with elements:
        NCBI760_full_image (Images), NCBI760_spots (Shapes)
Python · sddb client
from sddb import Catalog

ds = Catalog().dataset("oi8oxLDwPQUJJ4Yj0000")
ds.elements()          # inspect without downloading
sdata = ds.to_sdata()  # cached locally, reused
print(sdata)
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
artifact = db.Artifact.get("oi8oxLDwPQUJJ4Yj")   # stem uid: Lamin resolves it to the latest version

sdata = artifact.load()   # cache, then load into memory
group = artifact.open()   # stream without downloading
path  = artifact.cache()  # sync into the local cache, returns the path
Shell
# sddb client: download the .zarr into data/
sddb-cli download oi8oxLDwPQUJJ4Yj0000 --dest data/

# or lamin: cache the dataset and print its local path
lamin load https://lamin.ai/scverse/spatialdata-db/artifact/oi8oxLDwPQUJJ4Yj

# or connect once, then load by uid
lamin connect scverse/spatialdata-db
lamin load artifact --uid oi8oxLDwPQUJJ4Yj

License: CC BY-NC-SA 4.0 (noncommercial)

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Metadata

Technology
spatial transcriptomics
Organism
human
Tissue
skin of body
Condition
skin squamous cell carcinoma
Modality
RNA
Observations (spots)
621
Tier
silver
Chemistry
ST 2k
Magnification
20x
Resolution
15,872 × 15,872 px
mpp
0.366 µm/px
Size
203 MB
Sample ID
NCBI760
License
CC BY-NC-SA 4.0 NonCommercial
Published
Jun 22, 2020

Cite this dataset

doi.org/10.1016/j.cell.2020.05.039 ↗
BibTeX
@article{Ji_2020,
  title = {Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma},
  volume = {182},
  ISSN = {0092-8674},
  url = {http://dx.doi.org/10.1016/j.cell.2020.05.039},
  DOI = {10.1016/j.cell.2020.05.039},
  number = {2},
  journal = {Cell},
  publisher = {Elsevier BV},
  author = {Ji, Andrew L. and Rubin, Adam J. and Thrane, Kim and Jiang, Sizun and Reynolds, David L. and Meyers, Robin M. and Guo, Margaret G. and George, Benson M. and Mollbrink, Annelie and Bergenstråhle, Joseph and Larsson, Ludvig and Bai, Yunhao and Zhu, Bokai and Bhaduri, Aparna and Meyers, Jordan M. and Rovira-Clavé, Xavier and Hollmig, S. Tyler and Aasi, Sumaira Z. and Nolan, Garry P. and Lundeberg, Joakim and Khavari, Paul A.},
  year = {2020},
  month = July,
  pages = {497–514.e22}
}

Source: NCBI GEO ↗ · License: CC BY-NC-SA 4.0 ↗ · Reprocessed to SpatialData by SpatialData-DB