Collections / Spatial transcriptomic dissection of intratumoral heterogeneity and microenvironment in sinonasal and skull base adenoid cystic carcinoma

Spatial transcriptomic dissection of intratumoral heterogeneity and microenvironment in sinonasal and skull base adenoid cystic carcinoma

We profiled 6 patients with sinonasal-skull base adenoid cystic carcinoma by spatial transcriptomics (10x Genomics Visium) to characterize intratumoral heterogeneity and the immune landscape.

Datasets6
Size~182 MB
AssayVisium
Samplehuman · nasal cavity
KindOther
Flag a data issue
www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342687 ↗
Python · sddb client
from sddb import Catalog

cohort = Catalog().collection("geo-gse342687")
cohort.members        # the 6 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse342687")
coll.ordered_artifacts.to_dataframe()   # the 6 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse342687 --dest data/

Licenses: 6 NCBI GEO policy

Open in Vitessce
Visium
Human nasal cavity
GSM9936455
human nasal cavity adenoid cystic carcinoma 26.2 MB 3,628 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuenasal cavity
Conditionadenoid cystic carcinoma
Size26.2 MB
Spots3,628
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human nasal cavity
GSM9936459
human nasal cavity adenoid cystic carcinoma 52.4 MB 4,460 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuenasal cavity
Conditionadenoid cystic carcinoma
Size52.4 MB
Spots4,460
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human nasal cavity
GSM9936460
human nasal cavity adenoid cystic carcinoma 51.1 MB 3,791 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuenasal cavity
Conditionadenoid cystic carcinoma
Size51.1 MB
Spots3,791
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human nasal cavity
GSM9936458
human nasal cavity adenoid cystic carcinoma 14.7 MB 2,318 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuenasal cavity
Conditionadenoid cystic carcinoma
Size14.7 MB
Spots2,318
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human nasal cavity
GSM9936457
human nasal cavity adenoid cystic carcinoma 27.4 MB 3,276 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuenasal cavity
Conditionadenoid cystic carcinoma
Size27.4 MB
Spots3,276
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human nasal cavity
GSM9936456
human nasal cavity adenoid cystic carcinoma 10.5 MB 1,843 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuenasal cavity
Conditionadenoid cystic carcinoma
Size10.5 MB
Spots1,843
silver H&E NCBI GEO policy Open in Vitessce

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