Collections / Prenatal DBP Exposure Dysregulate Fetal-Placenta Spatial Transcriptomic Profiles

Prenatal DBP Exposure Dysregulate Fetal-Placenta Spatial Transcriptomic Profiles

Dibutyl phthalate (DBP), a phthalate congener, is widely utilized in consumer products and medication coatings. Women of reproductive age have a significant burden of DBP exposure. Prenatal DBP exposure is associated with adverse pregnancy/fetal outcomes in the offspring. However, the role of fetal sex and the general mechanisms underlying DBP exposure-associated adverse pregnancy outcomes are unclear. This study characterized fetal sex-specific spatial transcriptomic responses in gestational day 18.5 mouse placentas from fetuses with and without prenatal DBP exposure.

Datasets12
Size~471 MB
AssayVisium
Samplemouse · placenta
KindComparison
Flag a data issue
PMID:42523464 ↗
Download the whole collection
Python · sddb client 
from sddb import Catalog

cohort = Catalog().collection("geo-gse333401")
cohort.members        # the 12 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")
Install (Python 3.12+) Docs →
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse333401")
coll.ordered_artifacts.to_dataframe()   # the 12 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
Install (Python 3.12+) Docs →
Shell 
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse333401 --dest data/
Install (Python 3.12+) Docs →

Licenses: 12 NCBI GEO policy

Member datasets · 12
Open in Vitessce
Visium
Mouse placenta
GSM9762121
mouse placenta 46.8 MB 1,961 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size46.8 MB
Spots1,961
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762114
mouse placenta 25.3 MB 1,372 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size25.3 MB
Spots1,372
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762117
mouse placenta 32.3 MB 1,237 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size32.3 MB
Spots1,237
Magnificationother · 3.362 µm/px
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762125
mouse placenta 52.7 MB 2,411 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size52.7 MB
Spots2,411
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762119
mouse placenta 29.4 MB 1,861 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size29.4 MB
Spots1,861
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762115
mouse placenta 26.8 MB 1,624 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size26.8 MB
Spots1,624
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762118
mouse placenta 25.0 MB 859 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size25.0 MB
Spots859
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762123
mouse placenta 47.3 MB 1,598 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size47.3 MB
Spots1,598
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762124
mouse placenta 40.5 MB 1,587 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size40.5 MB
Spots1,587
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762120
mouse placenta 57.3 MB 2,080 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size57.3 MB
Spots2,080
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762116
mouse placenta 53.3 MB 2,087 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size53.3 MB
Spots2,087
bronze H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762113
mouse placenta 34.7 MB 2,281 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueplacenta
Size34.7 MB
Spots2,281
bronze H&E NCBI GEO policy Open in Vitessce

Cite this collection

doi.org/10.64898/2026.07.11.732137 ↗
BibTeX 
@article{Yang_2026,
  title = {Prenatal Dibutyl Phthalate Exposure Dysregulates Fetal-Placental Vascular Function and Placental Vasculature-Specific Lipid Metabolism},
  url = {http://dx.doi.org/10.64898/2026.07.11.732137},
  DOI = {10.64898/2026.07.11.732137},
  publisher = {openRxiv},
  author = {Yang, Xinran and Kadlec, Dilen and Schultz, Jordan and Craig, Zelieann R. and Zhou, Chi},
  year = {2026},
  month = July
}