Human coronary artery
GSM8658911
human coronary artery atherosclerosis 24.8 MB 799 spots silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Spots799
silver H&E
Collections / Spatial Gene Expression of Human Coronary Arteries Revealed the Molecular Features of Diffuse Intimal Thickening in Explanted Hearts
Spatial Gene Expression of Human Coronary Arteries Revealed the Molecular Features of Diffuse Intimal Thickening in Explanted Hearts
Diffuse intimal thickening (DIT) is a preclinical stage of atherogenesis in humans that does not exist in commonly used mouse models of atherosclerosis. Vascular smooth muscle cells (SMCs) are the predominant cell type that occupies the intimal and medial layers of human coronary arteries. The intimal layer of DIT is particularly prone to developing atherosclerosis later in life. Differences in the molecular features between the intimal and medial layers of DIT regions may represent the earliest changes that promote atherogenesis in humans, and can be studied by spatial molecular phenotyping.
Datasets6
Size~164 MB
AssayVisium
Samplehuman · coronary artery
KindOther
Download the whole collection
Python · sddb client
from sddb import Catalog
cohort = Catalog().collection("geo-gse283269")
cohort.members # the 6 datasets as a table
print(cohort.licenses()) # check the terms before you download
sdatas = cohort.to_dict() # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/") Python · lamindb
Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.
import lamindb as ln
db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse283269")
coll.ordered_artifacts.to_dataframe() # the 6 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()] Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse283269 --dest data/Licenses: 6 CC BY 4.0
Member datasets · 6
Human coronary artery
GSM8658913
human coronary artery atherosclerosis 34.0 MB 1,741 spots silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Spots1,741
silver H&E
Human coronary artery
GSM8658914
human coronary artery atherosclerosis 23.9 MB 999 spots silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Spots999
silver H&E
Human coronary artery
GSM8658916
human coronary artery atherosclerosis 32.9 MB 952 spots silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Spots952
silver H&E
Human coronary artery
GSM8658912
human coronary artery atherosclerosis 22.4 MB 732 spots silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Spots732
silver H&E
Human coronary artery
GSM8658915
human coronary artery atherosclerosis 25.7 MB 1,359 spots silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Spots1,359
silver H&E
Cite this collection
doi.org/10.3390/ijms26051949 ↗ BibTeX
@article{Li_2025,
title = {Spatial Gene Expression of Human Coronary Arteries Revealed the Molecular Features of Diffuse Intimal Thickening in Explanted Hearts},
volume = {26},
ISSN = {1422-0067},
url = {http://dx.doi.org/10.3390/ijms26051949},
DOI = {10.3390/ijms26051949},
number = {5},
journal = {International Journal of Molecular Sciences},
publisher = {MDPI AG},
author = {Li, Boaz and Leung, Samuel and Elishaev, Maria and Cheng, Wan Hei and Mocci, Giuseppe and Björkegren, Johan L. M. and Lai, Chi and Singh, Amrit and Wang, Ying},
year = {2025},
month = Feb,
pages = {1949}
}