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PhenoCycler-Fusion

Human bone marrow

25123538:AML2_183_Scan1

silver Interactive viewer acute myeloid leukemia ✓ Verified publication
Human bone marrow preview
print(sdata)
SpatialData object
├── Images
│     └── 'AML2_183_image': DataTree[cyx] (54, 10800, 7680), (54, 5400, 3840), (54, 2700, 1920), (54, 1350, 960), (54, 675, 480)
├── Shapes
│     ├── 'cell_boundaries': GeoDataFrame shape: (95273, 1) (2D shapes)
│     └── 'cell_boundaries_for_vitessce': GeoDataFrame shape: (95273, 2) (2D shapes)
└── Tables
      └── 'table': AnnData (95273, 54)
with coordinate systems:
    ▸ 'global', with elements:
        AML2_183_image (Images), cell_boundaries (Shapes), cell_boundaries_for_vitessce (Shapes)
Python · sddb client
from sddb import Catalog

ds = Catalog().dataset("qiNYqWzFkvOOrbYT0000")
ds.elements()          # inspect without downloading
sdata = ds.to_sdata()  # cached locally, reused
print(sdata)
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
artifact = db.Artifact.get("qiNYqWzFkvOOrbYT")   # stem uid: Lamin resolves it to the latest version

sdata = artifact.load()   # cache, then load into memory
group = artifact.open()   # stream without downloading
path  = artifact.cache()  # sync into the local cache, returns the path
Shell
# sddb client: download the .zarr into data/
sddb-cli download qiNYqWzFkvOOrbYT0000 --dest data/

# or lamin: cache the dataset and print its local path
lamin load https://lamin.ai/scverse/spatialdata-db/artifact/qiNYqWzFkvOOrbYT

# or connect once, then load by uid
lamin connect scverse/spatialdata-db
lamin load artifact --uid qiNYqWzFkvOOrbYT

License: CC0 1.0

View on Lamin ↗ Open in Vitessce ↗ Flag a data issue
Part of collection
figshare-25123538→
2 datasets · publication

Metadata

Technology
PhenoCycler-Fusion
Organism
human
Tissue
bone marrow
Condition
acute myeloid leukemia
Modality
protein
Observations (cells)
95,273
Tier
silver
Chemistry
PhenoCycler-Fusion 1
Staining
IF
Size
1.0 GB
Sample ID
25123538:AML2_183_Scan1
License
CC0 1.0
Published
Apr 12, 2024

Cite this dataset

doi.org/10.1016/j.cell.2024.04.013 ↗
BibTeX
@article{Bandyopadhyay_2024,
  title = {Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging},
  volume = {187},
  ISSN = {0092-8674},
  url = {http://dx.doi.org/10.1016/j.cell.2024.04.013},
  DOI = {10.1016/j.cell.2024.04.013},
  number = {12},
  journal = {Cell},
  publisher = {Elsevier BV},
  author = {Bandyopadhyay, Shovik and Duffy, Michael P. and Ahn, Kyung Jin and Sussman, Jonathan H. and Pang, Minxing and Smith, David and Duncan, Gwendolyn and Zhang, Iris and Huang, Jeffrey and Lin, Yulieh and Xiong, Barbara and Imtiaz, Tamjid and Chen, Chia-Hui and Thadi, Anusha and Chen, Changya and Xu, Jason and Reichart, Melissa and Martinez, Zachary and Diorio, Caroline and Chen, Chider and Pillai, Vinodh and Snaith, Oraine and Oldridge, Derek and Bhattacharyya, Siddharth and Maillard, Ivan and Carroll, Martin and Nelson, Charles and Qin, Ling and Tan, Kai},
  year = {2024},
  month = June,
  pages = {3120–3140.e29}
}

Source: doi.org ↗ · License: CC0 1.0 ↗ · Reprocessed to SpatialData by SpatialData-DB