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10x Xenium

Human breast

GSM7780154

bronze Interactive viewer breast cancer Provisional
Human breast preview
print(sdata)
SpatialData object
├── Images
│     ├── 'morphology_focus': DataTree[cyx] (1, 25779, 35411), (1, 12889, 17705), (1, 6444, 8852), (1, 3222, 4426), (1, 1611, 2213)
│     └── 'morphology_mip': DataTree[cyx] (1, 25779, 35411), (1, 12889, 17705), (1, 6444, 8852), (1, 3222, 4426), (1, 1611, 2213)
├── Labels
│     ├── 'cell_labels': DataTree[yx] (25779, 35411), (12889, 17705), (6444, 8852), (3222, 4426), (1611, 2213)
│     └── 'nucleus_labels': DataTree[yx] (25779, 35411), (12889, 17705), (6444, 8852), (3222, 4426), (1611, 2213)
├── Points
│     └── 'transcripts': DataFrame with shape: (31997227, 8) (3D points)
├── Shapes
│     ├── 'cell_boundaries': GeoDataFrame shape: (118752, 1) (2D shapes)
│     ├── 'cell_circles': GeoDataFrame shape: (118752, 2) (2D shapes)
│     └── 'nucleus_boundaries': GeoDataFrame shape: (118752, 1) (2D shapes)
└── Tables
      └── 'table': AnnData (118752, 313)
with coordinate systems:
    ▸ 'global', with elements:
        morphology_focus (Images), morphology_mip (Images), cell_labels (Labels), nucleus_labels (Labels), transcripts (Points), cell_boundaries (Shapes), cell_circles (Shapes), nucleus_boundaries (Shapes)
Python · sddb client
from sddb import Catalog

ds = Catalog().dataset("WDkrkf1aLtzImRTY0000")
ds.elements()          # inspect without downloading
sdata = ds.to_sdata()  # cached locally, reused
print(sdata)
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
artifact = db.Artifact.get("WDkrkf1aLtzImRTY")   # stem uid: Lamin resolves it to the latest version

sdata = artifact.load()   # cache, then load into memory
group = artifact.open()   # stream without downloading
path  = artifact.cache()  # sync into the local cache, returns the path
Shell
# sddb client: download the .zarr into data/
sddb-cli download WDkrkf1aLtzImRTY0000 --dest data/

# or lamin: cache the dataset and print its local path
lamin load https://lamin.ai/scverse/spatialdata-db/artifact/WDkrkf1aLtzImRTY

# or connect once, then load by uid
lamin connect scverse/spatialdata-db
lamin load artifact --uid WDkrkf1aLtzImRTY

License: NCBI GEO policy

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Metadata

Technology
10x Xenium
Organism
human
Tissue
breast
Condition
breast cancer
Modality
RNA
Observations (cells)
118,752
Transcripts
31,997,227
Tier
bronze
Size
3.6 GB
Sample ID
GSM7780154
License
NCBI GEO policy
Published
Oct 9, 2023

Cite this dataset

doi.org/10.1038/s41467-023-43458-x ↗
BibTeX
@article{Janesick_2023,
  title = {High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis},
  volume = {14},
  ISSN = {2041-1723},
  url = {http://dx.doi.org/10.1038/s41467-023-43458-x},
  DOI = {10.1038/s41467-023-43458-x},
  number = {1},
  journal = {Nature Communications},
  publisher = {Springer Science and Business Media LLC},
  author = {Janesick, Amanda and Shelansky, Robert and Gottscho, Andrew D. and Wagner, Florian and Williams, Stephen R. and Rouault, Morgane and Beliakoff, Ghezal and Morrison, Carolyn A. and Oliveira, Michelli F. and Sicherman, Jordan T. and Kohlway, Andrew and Abousoud, Jawad and Drennon, Tingsheng Yu and Mohabbat, Seayar H. and Taylor, Sarah E. B.},
  year = {2023},
  month = Dec
}

Source: NCBI GEO ↗ · License: NCBI GEO policy ↗ · Reprocessed to SpatialData by SpatialData-DB