Collections / Xenium spatial transcriptomics identifies mesenchymal fibroblast expansion and conserved fibrotic ECM programs in keloid

Xenium spatial transcriptomics identifies mesenchymal fibroblast expansion and conserved fibrotic ECM programs in keloid

In this study, we applied single-cell-resolution targeted Xenium spatial transcriptomics (Xenium ST) to define keloid-associated cellular and molecular programs within intact tissue architecture, with a focus on fibroblast populations and conserved pro-fibrotic gene programs linked to ECM remodeling across diverse ancestry.

Datasets2
Size~4.3 GB
Assay10x Xenium
Samplehuman · skin of body
KindComparison
Flag a data issue
www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341250 ↗
Python · sddb client
from sddb import Catalog

cohort = Catalog().collection("geo-gse341250")
cohort.members        # the 2 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse341250")
coll.ordered_artifacts.to_dataframe()   # the 2 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse341250 --dest data/

Licenses: 2 NCBI GEO policy

Open in Vitessce
10x Xenium
Human skin of body
GSM9902815
human skin of body keloid 1.6 GB 64,091 cells silver NCBI GEO policy
Technology10x Xenium
Organismhuman
Tissueskin of body
Conditionkeloid
Size1.6 GB
Cells64,091
silver NCBI GEO policy Open in Vitessce
Open in Vitessce
10x Xenium
Human skin of body
GSM9902814
human skin of body keloid 2.7 GB 86,647 cells silver NCBI GEO policy
Technology10x Xenium
Organismhuman
Tissueskin of body
Conditionkeloid
Size2.7 GB
Cells86,647
silver NCBI GEO policy Open in Vitessce

Cite this collection

No linked publication found — please cite the data source.