Visium HD
Macaque muscle tissue
GSM9380392
macaque muscle tissue 269 MB 688,434 bins bronze NCBI GEO policy
TechnologyVisium HD
Organismmacaque
Tissuemuscle tissue
Bins688,434
bronze NCBI GEO policy
Collections / geo-gse314035
geo-gse314035
Datasets2
Size~456 MB
TechnologyVisium HD
Samplemacaque · muscle tissue
KindPublication
Download the whole collection
Python · sddb client
from sddb import Catalog
cohort = Catalog().collection("geo-gse314035")
cohort.members # the 2 datasets as a table
print(cohort.licenses()) # check the terms before you download
sdatas = cohort.to_dict() # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/") Python · lamindb
Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.
import lamindb as ln
db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse314035")
coll.ordered_artifacts.to_dataframe() # the 2 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()] Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse314035 --dest data/Licenses: 2 NCBI GEO policy
About the study
Co-delivered PD-L1 rescues the protective efficacy mediated by an AAV-expressed HIV-1 bNAb
Adeno-associated virus (AAV)-delivered anti-HIV-1 broadly neutralizing antibodies (bNAbs) could prevent and treat HIV-1 infection but are limited by host immune responses, specifically anti-drug antibodies (ADA). We tested whether PD-L1-mediated immune shielding could improve the consistency of AAV-delivered bNAb expression from muscle tissue in rhesus macaques. AAV9.PD-L1 co-delivery with AAV9.3BNC117 reduced the occurrence of ADA and T cell responses and improved the durability of 3BNC117 expression for one year post administration. Importantly, 5 of 6 macaques that received co-delivered AAV9.PD-L1 vectors were protected against ten repeated SHIV AD8-EO challenges. Histopathological and spatial transcriptomic profiling showed that AAV9.PD-L1 co-delivery prevented severe local inflammation, muscle injury, and tertiary lymphoid structure formation at the administration site. Thus, immune shielding could serve as a strategy to prolong transgene expression from muscle-directed AAV-delivered biologics.
Member datasets · 2
Visium HD
Macaque muscle tissue
GSM9380393
macaque muscle tissue 187 MB 683,436 bins bronze NCBI GEO policy
TechnologyVisium HD
Organismmacaque
Tissuemuscle tissue
Bins683,436
bronze NCBI GEO policy
Cite this collection
No linked publication found — please cite the data source.