Immune dynamics in palmoplantar pustulosis (human skin, Visium HD).
from sddb import Catalog
cohort = Catalog().collection("geo-gse299051-palmoplantar-pustulosis")
cohort.members # the 2 datasets as a table
print(cohort.licenses()) # check the terms before you download
sdatas = cohort.to_dict() # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.
import lamindb as ln
db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse299051-palmoplantar-pustulosis")
coll.ordered_artifacts.to_dataframe() # the 2 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse299051-palmoplantar-pustulosis --dest data/Licenses: 2 NCBI GEO policy
@article{Lee_2026,
title = {Single-cell and spatial transcriptomics unveil myeloid–lymphoid cross talk and the dermal immune niche underlying palmoplantar pustulosis},
volume = {157},
ISSN = {0091-6749},
url = {http://dx.doi.org/10.1016/j.jaci.2026.01.028},
DOI = {10.1016/j.jaci.2026.01.028},
number = {6},
journal = {Journal of Allergy and Clinical Immunology},
publisher = {Elsevier BV},
author = {Lee, Hanjae and Lee, Juyoung and Ahn, Hyeok and Park, Kyunghyuk and Cha, Bukyung and Lee, Cheol and Kwon, Ohsang and Jo, Seong Jin and Kim, Jong-Il},
year = {2026},
month = June,
pages = {1339–1354}
}