Collections / Conserved principles of spatial biology define tumor heterogeneity and immunotherapy sensitivity

Conserved principles of spatial biology define tumor heterogeneity and immunotherapy sensitivity

Spatial transcriptomics experiments were performed on human patient pre-treatment biopsies for patients with either NSCLC or DLBCL. This was part of a larger study on pan-tumor spatial biology organization.

Datasets18
Size~2.5 GB
AssayVisium
Samplehuman · multiple
KindTime course
Flag a data issue
PMID:42664957 ↗
Python · sddb client
from sddb import Catalog

cohort = Catalog().collection("geo-gse292299")
cohort.members        # the 18 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse292299")
coll.ordered_artifacts.to_dataframe()   # the 18 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse292299 --dest data/

Licenses: 18 NCBI GEO policy

Open in Vitessce
Visium
Human brain
GSM8855712
human brain non-small cell lung carcinoma 187 MB 8,862 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuebrain
Conditionnon-small cell lung carcinoma
Size187 MB
Spots8,862
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human cheek
GSM8855715
human cheek non-small cell lung carcinoma 181 MB 5,247 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuecheek
Conditionnon-small cell lung carcinoma
Size181 MB
Spots5,247
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human pleura
GSM8855718
human pleura non-small cell lung carcinoma 65.7 MB 5,351 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuepleura
Conditionnon-small cell lung carcinoma
Size65.7 MB
Spots5,351
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human lung
GSM8855714
human lung non-small cell lung carcinoma 45.3 MB 2,131 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuelung
Conditionnon-small cell lung carcinoma
Size45.3 MB
Spots2,131
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human brain
GSM8855704
human brain non-small cell lung carcinoma 117 MB 6,907 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuebrain
Conditionnon-small cell lung carcinoma
Size117 MB
Spots6,907
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human lymph node
GSM8855720
human lymph node diffuse large B-cell lymphoma 116 MB 13,713 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuelymph node
Conditiondiffuse large B-cell lymphoma
Size116 MB
Spots13,713
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human pleura
GSM8855716
human pleura non-small cell lung carcinoma 29.5 MB 1,862 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuepleura
Conditionnon-small cell lung carcinoma
Size29.5 MB
Spots1,862
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human brain
GSM8855709
human brain non-small cell lung carcinoma 114 MB 5,705 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuebrain
Conditionnon-small cell lung carcinoma
Size114 MB
Spots5,705
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human lung
GSM8855717
human lung non-small cell lung carcinoma 204 MB 13,002 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuelung
Conditionnon-small cell lung carcinoma
Size204 MB
Spots13,002
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human lung
GSM8855707
human lung non-small cell lung carcinoma 61.0 MB 5,388 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuelung
Conditionnon-small cell lung carcinoma
Size61.0 MB
Spots5,388
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human lymph node
GSM8855705
human lymph node non-small cell lung carcinoma 123 MB 9,158 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuelymph node
Conditionnon-small cell lung carcinoma
Size123 MB
Spots9,158
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human lung
GSM8855710
human lung non-small cell lung carcinoma 63.7 MB 5,218 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuelung
Conditionnon-small cell lung carcinoma
Size63.7 MB
Spots5,218
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human brain
GSM8855706
human brain non-small cell lung carcinoma 116 MB 9,516 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuebrain
Conditionnon-small cell lung carcinoma
Size116 MB
Spots9,516
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human brain
GSM8855711
human brain non-small cell lung carcinoma 240 MB 12,242 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuebrain
Conditionnon-small cell lung carcinoma
Size240 MB
Spots12,242
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human brain
GSM8855703
human brain non-small cell lung carcinoma 136 MB 8,458 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuebrain
Conditionnon-small cell lung carcinoma
Size136 MB
Spots8,458
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human brain
GSM8855708
human brain non-small cell lung carcinoma 232 MB 10,078 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuebrain
Conditionnon-small cell lung carcinoma
Size232 MB
Spots10,078
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human lymph node
GSM8855719
human lymph node diffuse large B-cell lymphoma 136 MB 12,413 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuelymph node
Conditiondiffuse large B-cell lymphoma
Size136 MB
Spots12,413
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human brain
GSM8855713
human brain non-small cell lung carcinoma 379 MB 13,202 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuebrain
Conditionnon-small cell lung carcinoma
Size379 MB
Spots13,202
silver H&E NCBI GEO policy Open in Vitessce

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