from sddb import Catalog
cohort = Catalog().collection("geo-gse282721")
cohort.members # the 1 datasets as a table
print(cohort.licenses()) # check the terms before you download
sdatas = cohort.to_dict() # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.
import lamindb as ln
db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse282721")
coll.ordered_artifacts.to_dataframe() # the 1 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse282721 --dest data/Licenses: 1 NCBI GEO policy
FOXA1 is a prostate lineage-specifying transcription factor that is frequently dysregulated or mutated in prostate cancer (PCa). While FOXA1 has been reported to exhibit both PCa-promoting and -inhibitory functions, its role within an immune-proficient PCa context remains unclear. Here, we show that prostate-specific deletion of Foxa1 in Pten-deficient mice drives tumor progression by reprogramming luminal PCa cells toward a basal/squamous-like state and promoting an immunosuppressive tumor microenvironment. Histological and transcriptomic analyses reveal aggressive tumors with extensive basal/squamous features, a reactive stroma, and disorganized tissue architecture. Mechanistically, FOXA1 directly represses basal/squamous and inflammatory genes, which become activated upon its depletion. This is accompanied by an accumulation of immunosuppressive myeloid cells, dysfunctional T cells, and immunosuppressive cytokine signaling. Together, these findings demonstrate a tumor-suppressive role for FOXA1 as an enforcer of luminal identity, such that its loss drives basal/squamous de-differentiation, inflammatory response, and immunosuppression.
@article{Brea_2026,
title = {FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment},
volume = {17},
ISSN = {2041-1723},
url = {http://dx.doi.org/10.1038/s41467-026-71121-8},
DOI = {10.1038/s41467-026-71121-8},
number = {1},
journal = {Nature Communications},
publisher = {Springer Science and Business Media LLC},
author = {Brea, Lourdes and Shi, Hongshun and Keo, Viriya and Huang, Jing and Peng, Liu and Chu, Qi and Xie, Wanqing and Xie, Yinghua and Senthil, Sambhavi and Breneman, Matthew T. and Fan, Jie and Xie, Ping and Lu, Xiaodong and Degraff, David J. and Abdulkadir, Sarki A. and Yang, Ximing and Kosoff, David and Zhao, Jonathan C. and Zhang, Bin and Hu, Jian and Yu, Jindan},
year = {2026},
month = Mar
}