Collections / Hif2α–Lox mediated collagen remodelling is crucial for embryo invasion

Hif2α–Lox mediated collagen remodelling is crucial for embryo invasion

The mouse uterine gene expressions on pregnancy day 6 were investigated by Visium spatial transcriptome. Contributions of Hif2a-Lox axis was examined by comparing uterine-specific KO mice of Hif2a or Lox with their littermate control.

Datasets6

Size~86.6 MB

AssayVisium

Samplemouse · uterus

KindComparison

Flag a data issue

PMID:41803091 ↗

Download the whole collection

Client Lamin CLI

Python · sddb client

from sddb import Catalog

cohort = Catalog().collection("geo-gse274059")
cohort.members        # the 6 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")

Install (Python 3.12+) Docs →

Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse274059")
coll.ordered_artifacts.to_dataframe()   # the 6 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

Install (Python 3.12+) Docs →

Shell

# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse274059 --dest data/

Install (Python 3.12+) Docs →

Licenses: 6 NCBI GEO policy

Member datasets · 6

Visium

Mouse uterus

GSM8442781

mouse uterus 13.0 MB 408 spots bronze H&E NCBI GEO policy

TechnologyVisium

Organismmouse

Tissueuterus

Size13.0 MB

Spots408

Magnificationother · 3.623 µm/px

bronze H&E NCBI GEO policy

Visium

Mouse uterus

GSM8442780

mouse uterus 13.7 MB 454 spots bronze H&E NCBI GEO policy

TechnologyVisium

Organismmouse

Tissueuterus

Size13.7 MB

Spots454

Magnificationother · 3.624 µm/px

bronze H&E NCBI GEO policy

Visium

Mouse uterus

GSM8442777

mouse uterus 14.1 MB 533 spots bronze H&E NCBI GEO policy

TechnologyVisium

Organismmouse

Tissueuterus

Size14.1 MB

Spots533

Magnificationother · 3.622 µm/px

bronze H&E NCBI GEO policy

Visium

Mouse uterus

GSM8442779

mouse uterus 14.8 MB 436 spots bronze H&E NCBI GEO policy

TechnologyVisium

Organismmouse

Tissueuterus

Size14.8 MB

Spots436

Magnificationother · 3.622 µm/px

bronze H&E NCBI GEO policy

Visium

Mouse uterus

GSM8442778

mouse uterus 19.1 MB 662 spots bronze H&E NCBI GEO policy

TechnologyVisium

Organismmouse

Tissueuterus

Size19.1 MB

Spots662

Magnificationother · 3.623 µm/px

bronze H&E NCBI GEO policy

Visium

Mouse uterus

GSM8442776

mouse uterus 12.0 MB 369 spots bronze H&E NCBI GEO policy

TechnologyVisium

Organismmouse

Tissueuterus

Size12.0 MB

Spots369

bronze H&E NCBI GEO policy

Cite this collection

doi.org/10.1038/s41419-026-08485-8 ↗

BibTeX

@article{Aikawa_2026,
  title = {HIF2α-induced lysyl oxidase safeguards successful pregnancy by remodelling collagens at the feto-maternal interface},
  volume = {17},
  ISSN = {2041-4889},
  url = {http://dx.doi.org/10.1038/s41419-026-08485-8},
  DOI = {10.1038/s41419-026-08485-8},
  number = {1},
  journal = {Cell Death &amp; Disease},
  publisher = {Springer Science and Business Media LLC},
  author = {Aikawa, Shizu and Shimizu-Hirota, Ryoko and Sakashita, Akihiko and He, Xueting and Hiratsuka, Daiki and Ishizawa, Chihiro and Iida, Rei and Fukui, Yamato and Hiraoka, Takehiro and Matsuo, Mitsunori and Takeda, Norihiko and Ikawa, Masahito and Osuga, Yutaka and Hirota, Yasushi},
  year = {2026},
  month = Mar
}