Unique microglial states have been identified in Alzheimer’s disease (AD) model mice and postmortem AD brains. Although it has been well documented that amyloid-β accumulation induces the alteration of microglial states, the relationship between tau pathology and microglial states remains incompletely understood because of a lack of suitable AD models. In the present study, we generated a novel AD model mouse by the intracerebral administration of tau purified from human brains with primary age-related tauopathy into AppNL-G-F/MAPT double knock-in (dKI) mice.
from sddb import Catalog
cohort = Catalog().collection("geo-gse270382")
cohort.members # the 4 datasets as a table
print(cohort.licenses()) # check the terms before you download
sdatas = cohort.to_dict() # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.
import lamindb as ln
db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse270382")
coll.ordered_artifacts.to_dataframe() # the 4 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse270382 --dest data/Licenses: 4 NCBI GEO policy
@article{Nagata_2024,
title = {Tau Accumulation Induces Microglial State Alterations in Alzheimer’s Disease Model Mice},
volume = {11},
ISSN = {2373-2822},
url = {http://dx.doi.org/10.1523/eneuro.0260-24.2024},
DOI = {10.1523/eneuro.0260-24.2024},
number = {12},
journal = {eneuro},
publisher = {Society for Neuroscience},
author = {Nagata, Kenichi and Hashimoto, Shoko and Joho, Daisuke and Fujioka, Ryo and Matsuba, Yukio and Sekiguchi, Misaki and Mihira, Naomi and Motooka, Daisuke and Liu, Yu-Chen and Okuzaki, Daisuke and Kikuchi, Masataka and Murayama, Shigeo and Saido, Takaomi C. and Kiyama, Hiroshi and Sasaguri, Hiroki},
year = {2024},
month = Nov,
pages = {ENEURO.0260–24.2024}
}