Rat brainstem
GSM8125592
rat brainstem 23.4 MB 1,792 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismrat
Tissuebrainstem
Spots1,792
bronze H&E NCBI GEO policy
Collections / Neuromodulatory co-expression in cardiac vagal motor neurons of the Dorsal Motor Nucleus of the Vagus [spatial transcriptomics]
Neuromodulatory co-expression in cardiac vagal motor neurons of the Dorsal Motor Nucleus of the Vagus [spatial transcriptomics]
The activity of the cardiac vagal innervation is well known to be crucial to the maintenance of cardiac health, and to protect and recover the heart from injury. Only recently has this role been shown to depend on the activity of the underappreciated Dorsal Motor Nucleus of the Vagus (DMV). By combining neural tracing, transcriptomics, and 3D mapping in male and female Sprague Dawley rats we characterize cardiac-specific neuronal phenotypes in DMV. We find that the DMV cardiac-projecting neurons differentially express PACAP, CART, and synucleins, as well as evidence that they participate in neuromodulatory co-expression involving catecholamines. The significance of these findings is enhanced by previous knowledge of the role of PACAP at the heart and of the other neuromodulators in peripheral vagal targets.
Datasets8
Size~160 MB
AssayVisium
Samplerat · brainstem
KindOther
Download the whole collection
Python · sddb client
from sddb import Catalog
cohort = Catalog().collection("geo-gse260847")
cohort.members # the 8 datasets as a table
print(cohort.licenses()) # check the terms before you download
sdatas = cohort.to_dict() # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/") Python · lamindb
Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.
import lamindb as ln
db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse260847")
coll.ordered_artifacts.to_dataframe() # the 8 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()] Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse260847 --dest data/Licenses: 8 NCBI GEO policy
Member datasets · 8
Rat brainstem
GSM8125595
rat brainstem 19.1 MB 2,084 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismrat
Tissuebrainstem
Spots2,084
Magnificationother · 3.526 µm/px
bronze H&E NCBI GEO policy
Rat brainstem
GSM8125593
rat brainstem 18.8 MB 1,984 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismrat
Tissuebrainstem
Spots1,984
Magnificationother · 3.417 µm/px
bronze H&E NCBI GEO policy
Rat brainstem
GSM8125598
rat brainstem 15.6 MB 2,291 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismrat
Tissuebrainstem
Spots2,291
bronze H&E NCBI GEO policy
Rat brainstem
GSM8125597
rat brainstem 24.7 MB 2,132 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismrat
Tissuebrainstem
Spots2,132
Magnificationother · 3.460 µm/px
bronze H&E NCBI GEO policy
Rat brainstem
GSM8125594
rat brainstem 20.3 MB 1,723 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismrat
Tissuebrainstem
Spots1,723
Magnificationother · 3.421 µm/px
bronze H&E NCBI GEO policy
Rat brainstem
GSM8125596
rat brainstem 20.0 MB 2,182 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismrat
Tissuebrainstem
Spots2,182
Magnificationother · 3.547 µm/px
bronze H&E NCBI GEO policy
Rat brainstem
GSM8125599
rat brainstem 18.4 MB 2,199 spots bronze H&E NCBI GEO policy
TechnologyVisium
Organismrat
Tissuebrainstem
Spots2,199
Magnificationother · 3.680 µm/px
bronze H&E NCBI GEO policy
Cite this collection
doi.org/10.1016/j.isci.2024.110549 ↗ BibTeX
@article{Hornung_2024,
title = {Neuromodulatory co-expression in cardiac vagal motor neurons of the dorsal motor nucleus of the vagus},
volume = {27},
ISSN = {2589-0042},
url = {http://dx.doi.org/10.1016/j.isci.2024.110549},
DOI = {10.1016/j.isci.2024.110549},
number = {8},
journal = {iScience},
publisher = {Elsevier BV},
author = {Hornung, Eden and Robbins, Shaina and Srivastava, Ankita and Achanta, Sirisha and Chen, Jin and Cheng, Zixi Jack and Schwaber, James and Vadigepalli, Rajanikanth},
year = {2024},
month = Aug,
pages = {110549}
}