Collections / geo-gse243120

geo-gse243120

Datasets5
Size~225 MB
AssayVizgen MERSCOPE
Samplemouse · brain
KindPublication
Flag a data issue
10.1038/s41593-024-01682-8 ↗
Download the whole collection
Python · sddb client 
from sddb import Catalog

cohort = Catalog().collection("geo-gse243120")
cohort.members        # the 5 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")
Install (Python 3.12+) Docs →
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse243120")
coll.ordered_artifacts.to_dataframe()   # the 5 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
Install (Python 3.12+) Docs →
Shell 
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse243120 --dest data/
Install (Python 3.12+) Docs →

Licenses: 5 NCBI GEO policy

About the study

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8<sup>+</sup> T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

Member datasets · 5
Open in Vitessce
Vizgen MERSCOPE
Mouse brain
GSM7779546
mouse brain Alzheimer disease 53.2 MB 62,742 cells bronze NCBI GEO policy
TechnologyVizgen MERSCOPE
Organismmouse
Tissuebrain
ConditionAlzheimer disease
Size53.2 MB
Cells62,742
bronze NCBI GEO policy Open in Vitessce
Open in Vitessce
Vizgen MERSCOPE
Mouse brain
GSM7779548
mouse brain Alzheimer disease 41.9 MB 73,194 cells bronze NCBI GEO policy
TechnologyVizgen MERSCOPE
Organismmouse
Tissuebrain
ConditionAlzheimer disease
Size41.9 MB
Cells73,194
bronze NCBI GEO policy Open in Vitessce
Open in Vitessce
Vizgen MERSCOPE
Mouse brain
GSM7779544
mouse brain Alzheimer disease 45.7 MB 73,802 cells bronze NCBI GEO policy
TechnologyVizgen MERSCOPE
Organismmouse
Tissuebrain
ConditionAlzheimer disease
Size45.7 MB
Cells73,802
bronze NCBI GEO policy Open in Vitessce
Open in Vitessce
Vizgen MERSCOPE
Mouse brain
GSM7779547
mouse brain Alzheimer disease 44.5 MB 59,368 cells bronze NCBI GEO policy
TechnologyVizgen MERSCOPE
Organismmouse
Tissuebrain
ConditionAlzheimer disease
Size44.5 MB
Cells59,368
bronze NCBI GEO policy Open in Vitessce
Open in Vitessce
Vizgen MERSCOPE
Mouse brain
GSM7779545
mouse brain Alzheimer disease 39.5 MB 68,782 cells bronze NCBI GEO policy
TechnologyVizgen MERSCOPE
Organismmouse
Tissuebrain
ConditionAlzheimer disease
Size39.5 MB
Cells68,782
bronze NCBI GEO policy Open in Vitessce

Cite this collection

No linked publication found — please cite the data source.