Collections / Spatial transcriptome gene expression profile in 2 patients with Hashimoto's thyroiditis and 2 patients with papillary thyroid cancer combined with Hashimoto's thyroiditis.

Spatial transcriptome gene expression profile in 2 patients with Hashimoto's thyroiditis and 2 patients with papillary thyroid cancer combined with Hashimoto's thyroiditis.

Hashimoto's thyroiditis and papillary thyroid cancer are the most common thyroid disorders. We used spatial transcriptome sequencing (ST-seq) to investigate their potential relationship.

Datasets3
Size~102 MB
AssayVisium
Samplehuman · thyroid gland
KindReplicates
Flag a data issue
PMID:39178310 ↗
Python · sddb client
from sddb import Catalog

cohort = Catalog().collection("geo-gse230424")
cohort.members        # the 3 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse230424")
coll.ordered_artifacts.to_dataframe()   # the 3 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse230424 --dest data/

Licenses: 3 NCBI GEO policy

Open in Vitessce
Visium
Human thyroid gland
GSM7221916
human thyroid gland Hashimoto thyroiditis 27.1 MB 3,154 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuethyroid gland
ConditionHashimoto thyroiditis
Size27.1 MB
Spots3,154
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human thyroid gland
GSM7221918
human thyroid gland Hashimoto thyroiditis 39.1 MB 4,626 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuethyroid gland
ConditionHashimoto thyroiditis
Size39.1 MB
Spots4,626
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human thyroid gland
GSM7221915
human thyroid gland Hashimoto thyroiditis 35.7 MB 3,647 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuethyroid gland
ConditionHashimoto thyroiditis
Size35.7 MB
Spots3,647
silver H&E NCBI GEO policy Open in Vitessce

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