Collections / Time-series spatial transcriptomic analysis of murine small intestine (SI) undergoing irradiation induced injury-repair with and without LXR activation

Time-series spatial transcriptomic analysis of murine small intestine (SI) undergoing irradiation induced injury-repair with and without LXR activation

To unbiasedly characterize the spatial transcriptomics landscape of murine small intestine damage and repair, we performed a time-series spatial transcriptional analysis of total small intestinal tissue during the course of irradiation damage from mice receiving standard diet. Additionally, to understand the role of LXR activation during damage and repair, we also collected small intestine tissues from mice fed with GW3965 diet.

Datasets4
Size~222 MB
AssayVisium
Samplemouse · small intestine
KindComparison
Flag a data issue
PMID:39567700 ↗
Python · sddb client
from sddb import Catalog

cohort = Catalog().collection("geo-gse227742")
cohort.members        # the 4 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse227742")
coll.ordered_artifacts.to_dataframe()   # the 4 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse227742 --dest data/

Licenses: 4 NCBI GEO policy

Open in Vitessce
Visium
Mouse small intestine
GSM7106693
mouse small intestine 47.3 MB 4,190 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissuesmall intestine
Size47.3 MB
Spots4,190
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse small intestine
GSM7106691
mouse small intestine 58.4 MB 4,585 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissuesmall intestine
Size58.4 MB
Spots4,585
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse small intestine
GSM7106692
mouse small intestine 51.9 MB 4,881 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissuesmall intestine
Size51.9 MB
Spots4,881
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Mouse small intestine
GSM7106694
mouse small intestine 64.7 MB 4,859 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissuesmall intestine
Size64.7 MB
Spots4,859
silver H&E NCBI GEO policy Open in Vitessce

Cite this collection

No linked publication found — please cite the data source.