Collections / Visium Spatial transcriptomics analysis of human primary colorectal cancer

Visium Spatial transcriptomics analysis of human primary colorectal cancer

To reveal the spatial distribution and the difference gene expression pattern of cancer cells in colorectal cancer, Visium spatial transcriptomics of four CRC patients was applied

Datasets4
Size~240 MB
AssayVisium
Samplehuman · colorectum
KindReplicates
Flag a data issue
PMID:38446659 ↗
Python · sddb client
from sddb import Catalog

cohort = Catalog().collection("geo-gse226997")
cohort.members        # the 4 datasets as a table

print(cohort.licenses())              # check the terms before you download

sdatas = cohort.to_dict()             # {uid: SpatialData}, cached locally
# or keep the .zarr files in a folder of your choice:
# sdatas = cohort.to_dict(dest="data/")
Python · lamindb

Needs pip install lamindb and network access to the Lamin database, which is limited during the alpha. If it fails, use the Client tab.

import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
coll = db.Collection.get(key="geo-gse226997")
coll.ordered_artifacts.to_dataframe()   # the 4 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
Shell
# sddb client: download every member .zarr into data/
sddb-cli download --collection geo-gse226997 --dest data/

Licenses: 4 NCBI GEO policy

Open in Vitessce
Visium
Human colorectum
GSM7089857
human colorectum colorectal cancer 69.9 MB 4,676 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuecolorectum
Conditioncolorectal cancer
Size69.9 MB
Spots4,676
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human colorectum
GSM7089858
human colorectum colorectal cancer 37.6 MB 3,535 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuecolorectum
Conditioncolorectal cancer
Size37.6 MB
Spots3,535
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human colorectum
GSM7089856
human colorectum colorectal cancer 53.0 MB 3,737 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuecolorectum
Conditioncolorectal cancer
Size53.0 MB
Spots3,737
silver H&E NCBI GEO policy Open in Vitessce
Open in Vitessce
Visium
Human colorectum
GSM7089855
human colorectum colorectal cancer 79.5 MB 4,148 spots silver H&E NCBI GEO policy
TechnologyVisium
Organismhuman
Tissuecolorectum
Conditioncolorectal cancer
Size79.5 MB
Spots4,148
silver H&E NCBI GEO policy Open in Vitessce

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